INO80gruppen

The INO80 complex is a large, multi-subunit ATP-dependent chromatin remodeler found in eukaryotes. It belongs to the INO80/actin-related protein (Arp) family of remodelers, which play crucial roles in various DNA-related processes. The INO80 complex utilizes the energy from ATP hydrolysis to alter the structure of chromatin, primarily by sliding or ejecting nucleosomes. This manipulation of nucleosome positioning is essential for regulating access to the underlying DNA, thereby influencing gene expression, DNA replication, and DNA repair.

The INO80 complex is composed of approximately 15 subunits, with the catalytic subunit being either INO80A or INO80B depending on the organism. Other key subunits include Arp5, Arp8, and RuvBL1/2. This intricate assembly allows the complex to interact with both DNA and histone proteins, mediating its chromatin remodeling activity. Dysregulation of INO80 complex function has been implicated in various diseases, including cancer and developmental disorders, highlighting its significance in cellular homeostasis and genome stability. Research continues to elucidate the precise mechanisms by which the INO80 complex operates and its diverse biological functions.