IL36G
Interleukin-36 gamma, also known as IL36G, is a cytokine belonging to the IL-36 family, which is part of the larger IL-1 cytokine superfamily. These cytokines play crucial roles in the immune system, particularly in regulating inflammatory responses. IL36G is predominantly expressed in keratinocytes, the main cell type in the epidermis, and also found in other epithelial tissues.
The primary function of IL36G is to act as a pro-inflammatory mediator. It exerts its effects by
Dysregulation of IL36G signaling has been implicated in the pathogenesis of several inflammatory diseases. For instance,