IGFR
IGFR stands for Insulin-like Growth Factor Receptor. It is a transmembrane receptor protein that plays a crucial role in cellular growth, proliferation, and survival. The IGFR is activated by binding to insulin-like growth factors, primarily IGF-1 and IGF-2. This binding triggers a cascade of intracellular signaling pathways, including the PI3K/Akt pathway and the MAPK pathway, which ultimately influence gene expression and cellular processes.
The IGFR is composed of two extracellular alpha subunits and two transmembrane beta subunits, linked together
Dysregulation of IGFR signaling has been implicated in a variety of diseases, including cancer and diabetes.