IDH1IDH2mutaatiot
IDH1 and IDH2 are enzymes involved in the metabolism of isocitrate to alpha-ketoglutarate, a crucial step in the citric acid cycle. Mutations in these genes, IDH1 and IDH2, can lead to various biological and clinical consequences. IDH1 mutations are more commonly associated with neurological disorders, such as gliomas and acute myeloid leukemia, while IDH2 mutations are more frequently linked to hematological malignancies, including acute myeloid leukemia and acute lymphoblastic leukemia.
Mutations in IDH1 and IDH2 can result in the gain of enzymatic activity, leading to the production
The identification of IDH mutations has provided valuable insights into the molecular mechanisms underlying cancer development