ICP4

ICP4, or Interleukin-1 receptor-associated kinase 4, is a key protein involved in immune system signaling. It plays a crucial role in the Toll-like receptor (TLR) and Interleukin-1 receptor (IL-1R) signaling pathways. These pathways are essential for recognizing and responding to pathogens and initiating inflammatory responses.

ICP4 is a serine/threonine kinase that acts downstream of TLRs and IL-1Rs. Upon activation by these receptors, ICP4 phosphorylates other proteins, such as MyD88 and IRAKs, propagating the signal cascade. This leads to the activation of transcription factors like NF-κB, which in turn promote the expression of genes involved in inflammation and immunity.

Dysregulation of ICP4 activity has been linked to various autoimmune diseases and inflammatory conditions. Consequently, ICP4 has emerged as a potential therapeutic target. Inhibitors of ICP4 are being investigated for their potential to treat diseases characterized by excessive inflammation. Research into ICP4 continues to uncover its complex roles in immune homeostasis and disease pathogenesis.