Hyalein1s

Hyalein1s is a protein that belongs to the hyaluronan-binding protein family. It is primarily expressed in the central nervous system, where it plays a crucial role in the development and maintenance of neural circuits. Hyalein1s is known to interact with hyaluronan, a large glycosaminoglycan found in the extracellular matrix, and this interaction is essential for its function.

The protein is composed of 11 exons and encodes a 347-amino acid polypeptide. It contains several conserved domains, including a hyaluronan-binding domain, a PDZ-binding motif, and a coiled-coil region. The hyaluronan-binding domain is responsible for the interaction with hyaluronan, while the PDZ-binding motif allows hyalein1s to interact with other proteins containing PDZ domains.

Hyalein1s has been implicated in various neurological processes, including axon guidance, synapse formation, and neuronal migration. Mutations in the HYAL1 gene, which encodes hyalein1s, have been associated with neurological disorders, such as intellectual disability and epilepsy. However, the exact role of hyalein1s in these disorders is still not fully understood.

In addition to its role in the nervous system, hyalein1s has also been found in other tissues, such as the heart and the kidney. Its function in these tissues is not yet well characterized, but it is believed to play a role in tissue development and maintenance. Further research is needed to fully elucidate the functions and mechanisms of hyalein1s in different tissues and its potential implications in various diseases.