HoxD
HOXD refers to the HOXD gene cluster, one of the four HOX gene clusters in vertebrates. The HOXD cluster encodes a set of transcription factors that contain a homeobox DNA-binding domain and regulate patterning during embryonic development, particularly along the anterior-posterior axis and in limb formation.
In humans, the HOXD cluster is located on chromosome 2 and is organized in a linear array.
Functional roles of HOXD genes include contributions to axial skeleton patterning and limb morphogenesis, where they
Clinical significance is seen in congenital malformations linked to HOXD genes. HOXD13, in particular, is associated
Research notes: Because HOXD genes share regulatory landscapes and may coordinate with HOXA and HOXB clusters,