Hormoneand

Hormoneand is a hypothetical term used in discussions of endocrine and nervous system signaling to describe a proposed class of signaling molecules that would combine features of hormones and neurotransmitters.

In this concept, a hormoneand would be released into the bloodstream from a gland or organ and reach distant targets, like classic hormones, but could also operate locally at synapses or within neural circuits, like neurotransmitters. A hormoneand might engage both endocrine receptors on distant cells and fast-acting receptors in neurons, potentially yielding rapid signaling and longer-term genomic effects.

The term is not established in mainstream physiology; there is no consensus on a formal definition, chemical identities, or diagnostic criteria. It primarily appears in theoretical discussions, interdisciplinary thought experiments, or speculative science fiction, rather than as a recognized biological category.

Potential implications for research and medicine include the idea of dual-action therapeutics that address both systemic and neural aspects of disease. However, significant challenges exist, including receptor specificity, pharmacokinetics, the ability to cross the blood–brain barrier, safety considerations, and distinguishing hormoneand signaling from existing hormones and neurotransmitters.

See also: hormone, neurotransmitter, endocrine system, neuroendocrinology, signaling molecule.