HOXA2s

HOXA2s refers to the gene HOXA2, which is part of the HOXA gene cluster. This cluster is located on chromosome 7 in humans. Genes in this cluster play crucial roles in embryonic development, particularly in the formation of the head and neck region. HOXA2 specifically is involved in the development of the second pharyngeal arch. This arch is a transient embryonic structure that contributes to various facial features, including parts of the ear, jaw, and larynx. The HOXA2 gene encodes a transcription factor, a protein that binds to DNA and regulates the expression of other genes. During development, HOXA2's activity helps to specify the identity and fate of cells within the second pharyngeal arch. Dysregulation or mutations in HOXA2 can lead to developmental abnormalities affecting the structures derived from this arch. Research into HOXA2 contributes to our understanding of craniofacial development and congenital disorders affecting these areas.