HATP11b

HATP11b is a gene symbol that has appeared in some genomic annotations as an alias or potential misnomer for ATP11B, a member of the P4-ATPase family of aminophospholipid translocases. The official human gene symbol is ATP11B, and HATP11b is not widely used in current nomenclature.

ATP11B encodes a membrane-bound P4-ATPase that functions as a phospholipid flippase, utilizing energy from ATP hydrolysis to translocate aminophospholipids such as phosphatidylserine and phosphatidylethanolamine from the outer to the inner leaflet of the plasma membrane or endomembranes. Like other P4-ATPases, ATP11B forms a heteromeric complex with CDC50 family chaperones (for example, CDC50A), which are required for proper folding, trafficking, and activity.

The protein is predicted to localize to the Golgi apparatus and/or plasma membrane depending on cell type and associates with vesicular trafficking pathways. Expression analyses show broad but variable expression across tissues, with higher levels in certain epithelia and hematopoietic cells.

Functional studies suggest a role in maintaining membrane lipid asymmetry, endocytosis, and vesicle formation, with disruption affecting cell surface composition and trafficking. Clinical relevance remains to be fully established; genetic variants in ATP11B have been investigated for associations with disease, but findings require further replication.

When encountering the symbol HATP11b in literature, it is helpful to cross-check with ATP11B to ensure consistency, since ATP11B is the official and widely used name for this gene in human biology databases.