Guanine10N2met

Guanine10N2met refers to a modified nucleobase, specifically a derivative of guanine. Guanine is one of the five standard nucleobases found in nucleic acids like DNA and RNA. The modification in guanine10N2met involves a change at the N2 position of the guanine ring, introducing a methyl group. This specific modification is often studied in the context of epigenetics and DNA damage.

The methylation of guanine at the N2 position can occur through various biological processes or chemical reactions. While canonical DNA methylation primarily occurs at cytosine residues, N2-methylguanine (m2G) represents a different type of epigenetic modification. These modified bases can alter the structural and functional properties of DNA, potentially affecting DNA replication, transcription, and repair mechanisms. Research into m2G and its derivatives like guanine10N2met aims to understand their roles in cellular processes and their implications in diseases such as cancer.