GlyR3

GlyR3, also known as Glycine receptor subunit alpha-3, is a protein that in humans is encoded by the GLRA3 gene. This gene is part of the glycine receptor gene family. Glycine receptors are ligand-gated ion channels that play a crucial role in inhibitory neurotransmission in the central nervous system. They are pentameric structures composed of four distinct subunits, typically two alpha and two beta subunits, although homomeric alpha subunit receptors can also exist. GlyR3 is one of the alpha subunits and contributes to the overall function and pharmacological properties of the glycine receptor.

The GLRA3 gene is primarily expressed in the spinal cord and brainstem, areas where glycine is a major inhibitory neurotransmitter. GlyR3-containing glycine receptors are involved in regulating motor control, pain perception, and sensory processing. Mutations in genes encoding glycine receptor subunits, including those that might affect GLRA3, have been associated with various neurological disorders. Research continues to explore the specific roles and functional significance of the GlyR3 subunit in both normal physiological processes and disease states.