GAD65s
GAD65 refers to Glutamate Decarboxylase 65 kDa. It is one of two common isoforms of the enzyme glutamate decarboxylase (GAD) found in mammals. GAD65, along with its counterpart GAD67, is responsible for catalyzing the conversion of glutamate, an excitatory neurotransmitter, into gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter. This conversion is a critical step in regulating neuronal excitability in the central nervous system.
GAD65 is primarily found in presynaptic terminals of GABAergic neurons. Its expression is particularly concentrated in
Autoantibodies against GAD65 are of significant clinical interest. These autoantibodies are strongly associated with certain autoimmune