FrankStarlingprinsippet
The Frank-Starling prinsippet, also known as the Frank-Starling mekanismen, describes the relationship between ventricular end-diastolic volume and the stroke volume (or cardiac output). Within physiological limits, increasing venous return and ventricular filling raises the stroke volume, helping to balance the output of the heart’s two ventricles.
Mechanism: The force of cardiac contraction rises with stretch of the cardiac muscle fibers. As the end-diastolic
Clinical and physiological relevance: The principle explains how the heart adapts to changes in venous return
History: The concept is named for Otto Frank and Ernst Starling, who described the link between ventricular