Formin2

Formin2, also known as Formin-like protein 2, is a protein that in humans is encoded by the FORMN2 gene. This gene is part of the formin family of proteins, which are involved in the regulation of actin cytoskeleton dynamics. Formins are characterized by a conserved DAD (diaphanous autoinhibitory domain) and FH2 (formin homology 2) domain. Formin2 specifically plays a role in various cellular processes, including cell migration, cytokinesis, and cell adhesion. It is known to interact with profilin and other actin-binding proteins to modulate actin filament assembly. Studies have indicated that Formin2 can promote the elongation of actin filaments and also nucleate new filaments. The precise mechanisms and specific cellular contexts in which Formin2 exerts its functions are areas of ongoing research. Alterations in Formin2 expression or function have been implicated in certain disease states, although further investigation is required to fully understand these associations. The gene is widely expressed in various tissues.