FcRL4

FcRL4, also known as Fc receptor-like 4, is a transmembrane protein that belongs to the Fc receptor-like (FcRL) family. These proteins are structurally related to classical Fc receptors, which bind to antibodies, but they lack the ability to bind antibodies themselves. FcRL4 is primarily expressed on certain immune cells, particularly B lymphocytes and a subset of T lymphocytes.

The precise function of FcRL4 is not fully understood, and research is ongoing. However, studies suggest it plays a role in regulating immune cell activation and function. Its expression patterns have been linked to various immune responses and conditions. For example, altered FcRL4 expression has been observed in certain autoimmune diseases and lymphomas.

FcRL4 is encoded by the Fcrl4 gene. The protein is characterized by an extracellular region containing immunoglobulin-like domains, a transmembrane segment, and an intracellular tail. The intracellular signaling mechanisms downstream of FcRL4 engagement are still being investigated, but it is thought to interact with other signaling molecules within the cell. Its presence on specific immune cell populations indicates a potentially specialized role in modulating immune cell behavior within particular microenvironments. Further research is expected to elucidate its contributions to immune homeostasis and disease pathogenesis.