FcRIIACD32A

FcRIIACD32A, also known as CD32A, is a low-affinity receptor for the Fc portion of IgG antibodies. It is a type I transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily and is a member of the Fc gamma receptor (FcγR) family. FcRIIACD32A plays a crucial role in the immune system, mediating a variety of cellular responses following the binding of IgG-opsonized particles. These responses can include phagocytosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and the release of inflammatory mediators.

The expression of FcRIIACD32A is primarily found on myeloid cells, including monocytes, macrophages, and neutrophils, as well as some B cells and dendritic cells. Its low affinity for IgG means it typically binds to IgG antibodies that are aggregated or bound to a target, such as a pathogen or infected cell. Upon binding of IgG to FcRIIACD32A, intracellular signaling pathways are activated through the receptor's ITAM (immunoreceptor tyrosine-based activation motif) domain. This ultimately leads to cellular activation.

FcRIIACD32A is involved in various immunological processes, including the clearance of immune complexes, defense against microbial infections, and the regulation of inflammation. Dysregulation of FcRIIACD32A function has been implicated in several autoimmune diseases and inflammatory conditions, highlighting its importance in maintaining immune homeostasis. Research into FcRIIACD32A continues to explore its precise roles in health and disease, with potential implications for therapeutic strategies.