Farnesyylaatio
Farnesyylaatio is a post-translational modification (PTM) of proteins in which a farnesyl group is covalently attached to a protein. This modification is also known as protein farnesylation. The farnesyl group is a 15-carbon isoprenoid lipid molecule that is derived from the mevalonate pathway, which is responsible for cholesterol biosynthesis.
In farnesylation, the enzyme farnesyltransferase (FTase) catalyzes the transfer of the farnesyl group from its donor
Abnormal levels of farnesylated proteins have been implicated in various diseases, including cancer, where they contribute
Farnesylation is also involved in the pathogenesis of certain neurodegenerative diseases, such as Parkinson's disease, where
Studies on farnesylation have also provided insights into the biosynthesis of cholesterol and other isoprenoid compounds.