FRS1

FRS1, also known as Filamentous temperature sensitivity 1, is a protein-coding gene found in eukaryotes. It plays a crucial role in ribosome biogenesis, specifically in the processing of ribosomal RNA (rRNA). The protein encoded by FRS1 is a component of the 90-kDa ribosomal S6 kinase (RSK) complex and is involved in regulating the phosphorylation of ribosomal protein S6. This phosphorylation event is a key regulator of protein synthesis and cell growth. Studies have shown that FRS1 is essential for the proper assembly of the 40S ribosomal subunit. Mutations or disruptions in FRS1 can lead to impaired ribosome biogenesis, which can have significant consequences for cell viability and proliferation. In humans, FRS1 is expressed in various tissues and is thought to be particularly important during periods of rapid cell division, such as embryonic development. Research into FRS1 has provided insights into the intricate mechanisms controlling protein synthesis and has potential implications for understanding diseases associated with dysregulated cell growth.