FLG2

FLG2, also known as Filaggrin-2, is a protein encoded by the FLG2 gene in humans. This gene is located on chromosome 1. FLG2 is a member of the filaggrin family of proteins, which are known for their role in the structural integrity of the epidermis. Filaggrins are crucial for the formation and maintenance of the skin barrier, helping to prevent water loss and protect against external irritants.

While FLG2 shares homology with its well-studied counterpart, filaggrin (FLG), its precise function and contribution to skin barrier function are still areas of active research. Studies suggest that FLG2 may be involved in protein aggregation and organization within keratinocytes, the primary cell type of the epidermis. Mutations or altered expression of FLG2 could potentially impact skin barrier function, similar to the known effects of FLG mutations in conditions like atopic dermatitis.

Research into FLG2 is ongoing, aiming to elucidate its specific molecular mechanisms and its contribution to skin physiology and disease. Understanding the role of FLG2 may offer new insights into skin barrier disorders and potential therapeutic targets.