FGFRL1

FGFRL1, also known as Fibroblast Growth Factor Receptor Like 1, is a protein encoded by the FGFRL1 gene. It is a single-pass type I transmembrane receptor belonging to the immunoglobulin superfamily. FGFRL1 is characterized by its extracellular region containing immunoglobulin-like domains and a transmembrane domain. Unlike other FGF receptors, FGFRL1 does not possess the characteristic tyrosine kinase domain in its intracellular portion.

The exact biological function of FGFRL1 is still under investigation, but it is believed to play a role in developmental processes. It is thought to interact with fibroblast growth factors (FGFs), although its signaling mechanism is distinct from canonical FGF receptors. Some studies suggest FGFRL1 may act as a decoy receptor, sequestering FGF ligands and modulating their availability to other receptors. Its expression patterns have been observed in various tissues during embryonic development, hinting at a role in cell growth, differentiation, and tissue morphogenesis. Research continues to elucidate its specific ligands, downstream signaling pathways, and contributions to diverse physiological and pathological contexts.