FGFR14

FGFR14 is a gene that encodes a protein belonging to the fibroblast growth factor receptor family. These receptors are transmembrane proteins that play crucial roles in cell growth, differentiation, metabolism, and migration. FGFR14 specifically acts as a receptor for fibroblast growth factors (FGFs), which are signaling molecules that regulate a wide range of biological processes.

The protein encoded by FGFR14 is a type I transmembrane receptor with an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. Upon binding of FGFs to its extracellular domain, FGFR14 undergoes autophosphorylation and activates downstream signaling pathways, such as the MAPK and PI3K/Akt pathways. These pathways ultimately lead to changes in gene expression and cellular responses.

FGFR14 is expressed in various tissues and plays a role in development and tissue homeostasis. Aberrant FGFR14 signaling has been implicated in several diseases, including certain types of cancer, developmental disorders, and inflammatory conditions. Research into FGFR14 and its associated signaling pathways continues to be an active area of study, aiming to understand its precise functions and therapeutic potential.