FAAH2

FAAH2, also known as Fatty acid amide hydrolase 2, is an enzyme encoded by the FAAH2 gene in humans. It is a serine hydrolase that plays a role in the metabolism of fatty acid amides, which are a class of signaling molecules. FAAH2 is a member of the FAAH enzyme family, which also includes FAAH1 (commonly referred to as FAAH). While FAAH1 is primarily known for its role in degrading anandamide, a key endocannabinoid, FAAH2 appears to have a different substrate specificity, though research is ongoing to fully elucidate its precise biological functions and substrates.

The FAAH2 gene is located on chromosome 19. Expression patterns of FAAH2 have been observed in various tissues, including the brain, liver, and adipose tissue. Its activity is thought to contribute to the regulation of lipid metabolism and potentially other physiological processes. Studies have explored the therapeutic implications of modulating FAAH2 activity, particularly in areas related to metabolic disorders and pain. However, compared to FAAH1, FAAH2 has been less extensively studied, and its full physiological significance is still a subject of active research. Understanding the specific roles and substrates of FAAH2 is crucial for developing targeted therapeutic strategies.