Epsiprantel

Epsiprantel is a veterinary anthelmintic used to treat intestinal cestode infections in dogs and cats. It is effective against common tapeworm species such as Dipylidium caninum and Taenia spp. and is typically used when a tapeworm infection is diagnosed or suspected.

Mechanism of action: Epsiprantel disrupts the tegument of cestodes, leading to increased permeability and paralysis, with dislodgement from the intestinal wall. The expelled fragments are then passed in the feces.

Administration and dosage: Epsiprantel is given orally, usually as a single dose, with a repeat dose sometimes recommended depending on the product and infection. It may be available in tablet or suspension formulations for dogs and cats.

Pharmacokinetics: After administration, absorption is limited, and much of the drug remains in the gastrointestinal tract where it acts on the parasites.

Safety and adverse effects: It is generally well tolerated. Reported adverse effects are rare and may include mild vomiting or nausea shortly after administration. It should be used under veterinary supervision, particularly in young or ill animals.

Limitations and regulatory status: Epsiprantel is active against cestodes but not nematodes or trematodes. It is available as a veterinary drug in many countries; labels provide species-specific dosage and withdrawal times.