EphB2

EphB2 is a member of the Eph receptor tyrosine kinase family. These receptors are involved in cell-to-cell communication and play crucial roles in development and tissue homeostasis. EphB2 is a transmembrane protein that binds to ephrin-B ligands, which are also transmembrane proteins. This binding initiates a bidirectional signaling cascade. Forward signaling occurs within the EphB2-expressing cell, leading to a variety of cellular responses such as changes in cell adhesion, migration, and proliferation. Reverse signaling occurs within the ephrin-B-expressing cell, influencing its behavior in response to the EphB2 signal. EphB2 is widely expressed in various tissues, including the brain, liver, and kidney. In the nervous system, it is particularly important for neuronal development, synapse formation, and plasticity. Dysregulation of EphB2 signaling has been implicated in several diseases, including cancer and neurodegenerative disorders. Research continues to explore the complex roles of EphB2 in both normal physiological processes and disease pathogenesis.