EphB1

EphB1 is a member of the Eph receptor tyrosine kinase family. These receptors are involved in cell-to-cell communication and play critical roles in embryonic development, tissue repair, and cancer progression. EphB1 specifically binds to ephrin-B ligands, which are membrane-bound proteins. The interaction between EphB1 and ephrin-B triggers signaling cascades within both the EphB1-expressing cell and the ephrin-B-expressing cell, a process known as reciprocal signaling.

In developmental contexts, EphB1 signaling is crucial for processes such as neural development, cardiovascular formation, and limb patterning. It helps guide cell migration and establish tissue boundaries. Dysregulation of EphB1 has been implicated in various diseases. In cancer, EphB1 can act as either an oncogene or a tumor suppressor, depending on the specific cancer type and cellular context. It has been observed to influence tumor cell proliferation, invasion, and metastasis. Research into EphB1 continues to explore its precise functions and therapeutic potential in different biological processes and disease states.