EosinophilCationic
Eosinophil Cationic Protein (ECP), also known as eosinophil cationic protein or RNase3, is a basic, positively charged ribonuclease produced and stored in the specific granules of eosinophils. It is a member of the RNase A superfamily and is encoded by the RNASE3 gene.
Upon activation of eosinophils by cytokines such as IL-5 or GM-CSF, or by IgE-mediated stimuli, ECP is
Functionally, ECP has ribonuclease activity that can degrade RNA, exerting antiparasitic and antibacterial effects in vitro.
Clinically, elevated ECP levels can be detected in serum, plasma, sputum, or other body fluids and are
Measurement is typically performed by immunoassays such as ELISA. ECP is one of several eosinophil-derived mediators,