ESkompleksin

ESkompleksin is a protein complex involved in the regulation of cell division and the organization of the cytoskeleton in eukaryotic cells. The term "eskompleksin" is not a widely recognized or standardized name in scientific literature; however, it may refer to components or related proteins of the **Kinesin-6 family**, particularly those involved in spindle assembly and chromosome segregation during mitosis. One of the key proteins in this context is **Espl1** (Eskimo1), a component of the **MIS12 complex**, which plays a critical role in the formation of the kinetochore-microtubule attachment necessary for proper chromosome alignment and segregation.

The MIS12 complex, alongside other proteins like **Ndc80**, **Zwint**, and **Spc24/25**, contributes to the structural integrity of the kinetochore, a protein structure on chromosomes where spindle microtubules attach. This complex helps ensure accurate chromosome segregation during cell division, preventing errors that could lead to genetic instability or diseases such as cancer. Disruptions in these pathways have been linked to chromosomal abnormalities and mitotic defects.

Research on these proteins has primarily focused on model organisms like yeast (*Saccharomyces cerevisiae*) and has provided insights into broader cellular mechanisms. Studies have also explored their potential roles in human diseases, particularly those involving mitotic errors. While the term "eskompleksin" is not formally documented in peer-reviewed literature, it may arise from discussions or studies involving related proteins or complexes in non-standardized nomenclature. Further research continues to elucidate the precise functions and interactions of these components in cell division and their broader implications for human health.