ENTPD4

ENTPD4, also known as ectonucleoside triphosphate diphosphohydrolase 4, is an enzyme encoded by the ENTPD4 gene in humans. This gene is located on chromosome 13. ENTPD4 belongs to the ectonucleoside triphosphate diphosphohydrolase family, which are enzymes that hydrolyze extracellular nucleoside triphosphates and diphosphates. Specifically, ENTPD4 is thought to play a role in regulating the extracellular concentration of ATP and ADP. These nucleotides are important signaling molecules that can affect various cellular processes, including inflammation, platelet aggregation, and neurotransmission. The precise physiological functions of ENTPD4 are still under investigation, but it is believed to be involved in processes such as cell proliferation, differentiation, and immune responses. Dysregulation of ENTPD4 activity has been implicated in certain diseases, though further research is needed to fully understand these associations. The enzyme is expressed in various tissues, with notable presence in the brain, liver, and kidney. Its catalytic activity is dependent on the presence of divalent cations like calcium and magnesium.