Dsg1e
Dsg1e, also known as desmoglein 1e, is a protein encoded by the DSG1 gene in humans. It is a member of the desmoglein family of cadherin proteins, which are essential components of desmosomes. Desmosomes are specialized cell junctions that provide strong adhesive connections between cells, particularly in epithelial tissues. Dsg1e is predominantly expressed in the epidermis, the outermost layer of the skin, and plays a critical role in maintaining epidermal integrity and barrier function.
The desmogleins are transmembrane glycoproteins that form homophilic and heterophilic interactions with other desmogleins on adjacent