Dglucaric

D-glucaric acid is a hexaric acid derived from glucose by oxidation of both terminal carbon atoms, yielding a six-carbon diacid with carboxyl groups at the ends. In chemical literature it is also referred to as saccharic acid; the compound is highly water-soluble and contains multiple hydroxyl groups, making it a polyfunctional dicarboxylic acid.

Natural occurrence and production: D-glucaric acid occurs in trace amounts in some fruits and vegetables and can be formed by microbial oxidation of glucose in nature. Industrial production typically involves the oxidation of glucose or related sugars or sugar alcohols, using chemical oxidants or catalytic systems, followed by purification to isolate the diacid.

Applications: The diacid functionality of D-glucaric acid allows it to be explored as a bio-based building block for polymer production, including potential polyesters and other derivatives. Salts of the compound, such as calcium D-glucarate and magnesium D-glucarate, are commercially available and marketed as dietary supplements claimed to support detoxification, though robust clinical evidence and regulatory status vary by region.

Safety and regulation: D-glucaric acid itself is a non-volatile, low-toxicity chemical that is handled with standard acid- and base-handling precautions. Supplements based on glucarate salts fall under food or nutraceutical regulatory frameworks and should be used in accordance with local guidelines and recommendations.