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DSXF

DsxF is a gene located on the X chromosome that plays a crucial role in the development of male sexual characteristics. It is part of the Dsx family of genes, which are involved in sex determination and differentiation in mammals. The DsxF gene is expressed in the developing testes and is essential for the formation of the Sertoli cells, which are crucial for the development of sperm and the maintenance of the blood-testis barrier.

DsxF is also involved in the regulation of other genes that are important for male sexual differentiation.

Mutations in the DsxF gene can lead to disorders of sex development (DSD). One of the most

DsxF is a highly conserved gene, with orthologs found in various mammals, including humans, mice, and rats.

For
example,
it
regulates
the
expression
of
the
Amh
gene,
which
encodes
anti-Müllerian
hormone.
This
hormone
is
essential
for
the
regression
of
the
Müllerian
ducts,
which
are
structures
that
develop
into
the
female
reproductive
system.
well-known
DSDs
associated
with
DsxF
mutations
is
46,XY
disorder
of
sex
development
(DSD),
also
known
as
Swyer
syndrome.
In
this
condition,
individuals
have
a
46,XY
karyotype
but
do
not
develop
typical
male
sexual
characteristics
due
to
the
lack
of
functional
DsxF
protein.
This
conservation
suggests
that
the
functions
of
DsxF
are
critical
for
male
sexual
differentiation
across
different
species.
The
study
of
DsxF
and
its
role
in
sex
determination
continues
to
be
an
active
area
of
research
in
the
field
of
developmental
biology
and
genetics.