DOPAdekarboksylaza

DOPAdekarboksylaza, also known as aromatic L-amino acid decarboxylase (AADC) or simply DDC, is an enzyme that catalyzes the removal of a carboxyl group from a molecule. It plays a critical role in the biosynthesis of neurotransmitters and hormones. Specifically, it is a key enzyme in the pathway for producing dopamine from L-DOPA, as well as serotonin from 5-hydroxytryptophan. This decarboxylation reaction is essential for the proper functioning of the nervous system and other physiological processes.

The enzyme is found in various tissues, including the brain, adrenal glands, and intestines. Its activity is crucial for maintaining adequate levels of these important signaling molecules. Genetic mutations or deficiencies in DOPAdekarboksylaza can lead to severe neurological disorders characterized by a lack of dopamine and serotonin, impacting motor control, mood, and behavior. Research into DOPAdekarboksylaza is ongoing, aiming to understand its precise mechanisms and explore potential therapeutic interventions for related diseases.