Cytoadherence

Cytoadherence refers to the phenomenon where cells, particularly pathogens like malaria parasites, adhere to host cells. This adhesion is mediated by specific molecular interactions between molecules on the surface of the pathogen and receptors on the surface of the host cell. In the context of malaria, infected red blood cells can adhere to the endothelial cells of blood vessels, a process crucial for parasite survival and pathogenesis. This sequestration of infected cells in vital organs can lead to serious complications. The molecules involved in cytoadherence are diverse and often species-specific, representing targets for therapeutic intervention. Understanding the mechanisms and molecules underlying cytoadherence is vital for developing strategies to combat infectious diseases and inflammatory conditions.