CysLT2R

CysLT2R, also known as cysteinyl leukotriene receptor 2, is a G-protein-coupled receptor that plays a significant role in the inflammatory response. It is primarily expressed on the surface of immune cells, such as mast cells, basophils, and eosinophils. CysLT2R is activated by cysteinyl leukotrienes, a family of lipid mediators that are produced by the metabolism of arachidonic acid. Upon activation, CysLT2R triggers a cascade of intracellular events that lead to the release of inflammatory mediators, such as histamine and cytokines, and the recruitment of additional immune cells to the site of inflammation. This process contributes to the development of various inflammatory diseases, including asthma, allergic rhinitis, and atopic dermatitis. CysLT2R has emerged as a promising therapeutic target for the treatment of these conditions, and several CysLT2R antagonists have been developed and are currently undergoing clinical trials. However, the precise mechanisms by which CysLT2R regulates inflammation remain an active area of research.