CuC2

CUC2, also known as Cell Cycle Controller 2, is a gene that plays a crucial role in regulating the cell cycle in eukaryotic organisms. This gene encodes a protein that acts as a subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C). The APC/C is a ubiquitin ligase that targets specific proteins for degradation, thereby controlling the transition between different phases of the cell cycle. CUC2 specifically interacts with other APC/C subunits to ensure the proper timing of these events, particularly the degradation of proteins that inhibit cell cycle progression. Mutations or dysregulation of CUC2 can lead to uncontrolled cell division and are implicated in various diseases, including cancer. Research into CUC2's function continues to shed light on the intricate mechanisms governing cell division and its importance for maintaining cellular homeostasis. Its precise role in substrate recognition and ubiquitination within the APC/C complex is an active area of investigation, contributing to our understanding of cell cycle control and the development of targeted therapies for cell proliferation disorders.