Csm1p
Csm1p is a meiosis-specific kinetochore-associated protein in the budding yeast Saccharomyces cerevisiae, encoded by the CSM1 gene. It is a core component of the monopolin complex, which also includes Lrs4p and, during meiosis I, Mam1p. The complex functions to co-orient sister chromatids at the centromere, promoting their attachment to a single spindle pole and enabling the reductional division that characterizes meiosis I.
Csm1p participates in establishing monopolar kinetochore attachments during meiosis I, thereby ensuring that sister chromatids are
Csm1p localizes to centromeric regions during meiosis I and interacts with Lrs4p to form the core monopolin
Csm1p is thought to contain coiled-coil regions that enable stable interactions with Lrs4p and Mam1p, facilitating
Csm1p is a component of the monopolin complex, which also involves Lrs4p and Mam1p, and plays a