Cohesinrelated
Cohesin-related refers to a group of proteins that are structurally and functionally related to cohesin, a large protein complex involved in various cellular processes. Cohesin is a ring-shaped complex composed of four subunits: SMC1, SMC3, SA1, and SA2. It plays a crucial role in chromosome segregation during cell division, DNA repair, and gene regulation.
Cohesin-related proteins share structural similarities with cohesin, particularly in their SMC (Structural Maintenance of Chromosomes) domains.
Other cohesin-related proteins include WAPL (WAPL, cohesin, and PML complex), which is involved in DNA repair
Cohesin-related proteins are essential for maintaining genomic stability and proper gene expression. Dysregulation of these proteins