Clonotypesgroups

Clonotypesgroups are a concept used in immunology and bioinformatics to describe collections of T cell or B cell receptor sequences that share a common origin or specificity. A clonotype itself refers to a lymphocyte that expresses a unique T cell receptor (TCR) or B cell receptor (BCR) gene rearrangement. When multiple lymphocytes are found to have identical or highly similar TCR or BCR sequences, they are considered to belong to the same clonotype. The term "clonotypesgroups" emerges when researchers identify and analyze these groups of related clonotypes.

These groups are significant because they often represent expansions of lymphocytes that have recognized and responded to a specific antigen. For instance, during an infection or in response to a vaccine, a particular antigen may activate a small number of lymphocytes with specific receptors. These activated lymphocytes then proliferate, generating a large population of cells all possessing the same TCR or BCR. The identification of these clonotypesgroups can therefore provide insights into immune responses, such as identifying the antigens that have been encountered by an individual or the repertoire of immune cells available to combat disease. Analyzing clonotypesgroups is a fundamental aspect of immune repertoire sequencing and plays a role in understanding immune memory, autoimmunity, and cancer immunology.