Chlorpromazines

Chlorpromazine, also known by brand names such as Thorazine and Largactil, is a medication primarily used to treat schizophrenia and other psychotic disorders. It belongs to a class of drugs called typical antipsychotics. Beyond its use in psychosis, chlorpromazine has also been employed in managing nausea and vomiting, severe pain, and in some cases of acute mania. Its mechanism of action involves blocking dopamine receptors in the brain, which is believed to alleviate the symptoms of psychosis.

The discovery of chlorpromazine in the 1950s marked a significant advancement in psychiatric treatment, offering an alternative to the more restrictive and often ineffective methods previously available. Its introduction led to the deinstitutionalization of many patients, allowing them to live outside of mental hospitals. However, like all medications, chlorpromazine can have side effects. Common adverse effects include drowsiness, dizziness, dry mouth, and blurred vision. More serious side effects can include movement disorders such as tardive dyskinesia and neuroleptic malignant syndrome. It is typically administered orally or via injection. While newer antipsychotics are available, chlorpromazine remains a valuable therapeutic option in certain clinical situations.