Chelerythrine

Chelerythrine is a quaternary ammonium alkaloid found in plants of the Papaveraceae family, notably greater celandine (Chelidonium majus). It is one of several isoquinoline alkaloids present in this species. Chemically, chelerythrine is characterized by its benzophenanthridine structure. It exists as a mixture of enantiomers, with the naturally occurring form being levorotatory.

Research into chelerythrine has explored its potential biological activities. Studies have indicated that it possesses properties such as antimicrobial, anti-inflammatory, and cytotoxic effects in vitro. Some investigations have focused on its interaction with cellular processes, including DNA intercalation and enzyme inhibition. However, much of this research is preclinical, and its efficacy and safety in human therapeutic applications have not been established.

The isolation and purification of chelerythrine involve standard phytochemical techniques. Its presence in traditional herbal remedies, particularly those derived from greater celandine, has contributed to its study. While chelerythrine has shown promise in laboratory settings, it is not a widely used pharmaceutical agent. Further research is required to fully understand its pharmacological profile and potential clinical utility.