CetYZ

CetYZ is a protein that plays a crucial role in the bacterial cell wall synthesis. It is a component of the penicillin-binding protein (PBP) family, which are enzymes that catalyze the cross-linking of peptidoglycan, a major component of the bacterial cell wall. CetYZ is specifically involved in the transpeptidation reaction, where it catalyzes the formation of peptide bonds between the amino acids of adjacent peptidoglycan strands.

CetYZ is encoded by the cetYZ gene, which is found in many Gram-positive bacteria. The protein consists of two domains: a catalytic domain and a membrane-anchoring domain. The catalytic domain is responsible for the transpeptidation reaction, while the membrane-anchoring domain helps to position the protein within the cell membrane.

CetYZ is a target for several antibiotics, including cephalosporins and penicillins. These antibiotics inhibit the transpeptidation reaction, leading to the disruption of the bacterial cell wall and ultimately, cell death. However, the emergence of antibiotic-resistant strains has led to the development of new antibiotics that target CetYZ and other PBPs.

CetYZ is also involved in the regulation of cell wall synthesis. It has been shown to interact with other proteins involved in peptidoglycan synthesis, such as MurG and MurF. This interaction helps to coordinate the synthesis of peptidoglycan and ensure the proper formation of the bacterial cell wall.