CalcitoninSalmon

Calcitonin Salmon, also known as salmon calcitonin, is a peptide hormone used therapeutically in medicine. The salmon form is derived from salmon and is more potent and longer-acting than human calcitonin due to higher receptor affinity. It is administered to influence calcium metabolism and bone turnover.

Mechanism of action and effects: Calcitonin salmon binds to calcitonin receptors on osteoclasts, reducing bone resorption and thereby lowering serum calcium levels. It can also modestly affect renal calcium handling. The net result is decreased osteoclastic activity and changes in calcium balance, with effects that are typically modest and dose-related.

Medical uses: It has been used to treat hypercalcemia of malignancy and other hypercalcemic states, as well as certain bone disorders such as postmenopausal osteoporosis and Paget disease of bone. In osteoporosis, salmon calcitonin is generally considered a secondary or alternative option when other therapies are unsuitable or not tolerated. Its use for osteoporosis has declined in many regions due to questions about long-term efficacy and safety.

Forms and administration: Calcitonin salmon is available in injectable forms (subcutaneous or intramuscular) and as an intranasal spray. The nasal form offers convenient administration, but nasal absorption can be variable and local nasal irritation is common.

Safety and regulatory status: Adverse effects may include nasal irritation, rhinitis, flushing, nausea, and injection-site reactions. Long-term use has been associated with concerns about cancer risk in some evaluations, leading to restricted or discouraged use for osteoporosis in several places. It remains an option for specific hypercalcemic conditions and careful, short-term management under medical supervision.