Ca2calmodulinactivated

Ca2calmodulinactivated refers to a class of enzymes that are activated by the binding of calcium ions (Ca2+) to calmodulin, a ubiquitous calcium-binding protein. This activation mechanism is crucial in various biological processes, including muscle contraction, neurotransmission, and gene expression. Calmodulin, when bound to calcium ions, undergoes a conformational change that exposes hydrophobic pockets, allowing it to interact with and activate target enzymes. These enzymes typically possess a calmodulin-binding domain that recognizes and binds to the activated calmodulin. The Ca2calmodulinactivated enzymes play a vital role in cellular signaling pathways, regulating processes such as protein phosphorylation, protein degradation, and ion channel activity. The activation of these enzymes by calcium-calmodulin complex is tightly regulated to ensure precise control over cellular functions.