Ca2Aufnahme
Ca2Aufnahme refers to the process by which calcium ions (Ca2+) are transported into cells or into intracellular storage compartments. It is a central aspect of cellular signaling and homeostasis, influencing muscle contraction, neurotransmitter release, enzyme activity, and gene expression. Calcium uptake occurs across the plasma membrane and into organelles such as the endoplasmic reticulum and mitochondria.
Across the plasma membrane, Ca2+ enters through various pathways. Voltage-gated calcium channels respond to membrane depolarization,
Intracellular organelles also take up Ca2+. The endoplasmic reticulum and sarcoplasmic reticulum sequester Ca2+ via SERCA
Physiologically, Ca2Aufnahme in epithelia supports absorption and reabsorption. In the intestine, transcellular Ca2+ uptake involves TRPV6
Dysregulation of Ca2Aufnahme can contribute to disorders including hypocalcemia, hypercalcemia, arrhythmias, and skeletal diseases. Experimental approaches