CYP3A4s

CYP3A4 is a gene that provides instructions for making an enzyme called cytochrome P450 3A4. This enzyme is primarily found in the liver and the intestines. It is a member of the cytochrome P450 superfamily of enzymes, which are involved in metabolizing (breaking down) a wide variety of substances. CYP3A4 plays a crucial role in drug metabolism, processing approximately half of all prescription drugs currently in use. It is also involved in the metabolism of endogenous compounds like steroids and bile acids. The activity of CYP3A4 can be influenced by genetic variations, as well as by other medications and certain foods, leading to variability in drug responses among individuals. This enzyme's broad substrate specificity and significant role in drug clearance make it a key factor in drug-drug interactions and the efficacy and toxicity of many pharmaceuticals. Understanding CYP3A4's function is essential for optimizing drug therapy and predicting potential adverse effects.