COPIImediated

COPII-mediated transport is a process in eukaryotic cells that involves the COPII coatomer complex, which is responsible for the formation of coated vesicles. These vesicles are essential for the transport of proteins and lipids from the endoplasmic reticulum (ER) to the Golgi apparatus. The COPII complex consists of seven subunits, including Sar1, Sec23, Sec24, Sec13, Sec31, and two copies of Sec12 and Sec24. The COPII complex binds to the ER membrane and recruits cargo proteins, which are then enclosed within a coated vesicle. The coat is then removed, and the vesicle buds off from the ER membrane. The COPII-mediated transport is crucial for various cellular processes, including protein sorting, modification, and secretion. Mutations in COPII components have been linked to several diseases, such as Alzheimer's disease and Parkinson's disease, highlighting the importance of this transport pathway in maintaining cellular homeostasis.