CDKtsükliini

CDKtsükliin refers to cyclins, which are a group of proteins that regulate the cell cycle. Cyclins are named for their ability to undergo periodic synthesis and degradation, which is crucial for the progression of the cell cycle through its various phases. They act as regulatory subunits for cyclin-dependent kinases (CDKs), which are enzymes that phosphorylate other proteins. The binding of a cyclin to its partner CDK forms an active kinase complex that drives specific events in cell division.

There are several classes of cyclins, each associated with different phases of the cell cycle. For example, cyclins D and E are typically involved in the G1 phase, promoting entry into the S phase where DNA replication occurs. Cyclins A and B are primarily active during the S, G2, and M phases, ensuring proper DNA replication and chromosome segregation. The precise temporal and spatial expression of cyclins, along with their interaction with specific CDKs, is tightly controlled to maintain genomic stability and prevent uncontrolled cell proliferation. Dysregulation of cyclin and CDK activity is a hallmark of many cancers, making them important targets for therapeutic interventions.