CDK46containing

CDK46containing refers to a protein domain or motif that is part of the larger cyclin-dependent kinase 4 (CDK4) and cyclin-dependent kinase 6 (CDK6) proteins. These kinases play a crucial role in the cell cycle, specifically in regulating the transition from the G1 phase to the S phase. CDK4 and CDK6, in complex with their regulatory partners cyclin D1, D2, and D3, phosphorylate the retinoblastoma protein (Rb). This phosphorylation event releases E2F transcription factors, which then promote the expression of genes necessary for DNA replication and cell cycle progression. Dysregulation of CDK4/6 activity is frequently observed in various cancers, leading to uncontrolled cell proliferation. Therefore, the CDK46containing region is a key functional component of these proteins and a target for therapeutic interventions aimed at cancer treatment. Research into the structure and function of the CDK46containing domain helps in understanding its role in normal cell biology and disease pathogenesis.