CD8KoRezeptoren
CD8Korezeptoren are co-receptors expressed on CD8+ T lymphocytes that facilitate the recognition of antigenic peptides presented by MHC class I molecules. They are typically assembled as CD8αβ heterodimers on most peripheral CD8+ T cells, while a CD8αα homodimer form is found on certain thymocytes and intraepithelial lymphocytes. As co-receptors, they work in concert with the T-cell receptor (TCR) to enhance sensitivity to peptide–MHC I complexes.
Structurally, CD8Korezeptoren have an extracellular domain that binds to the α3 domain of MHC class I. Their
Functionally, CD8Korezeptoren increase the avidity and stability of the TCR–peptide–MHC I interaction, lowering the activation threshold
Expression patterns reflect lineage: CD8αβ is predominant on circulating cytotoxic T cells, whereas CD8αα is enriched